Hyalomatrix® Clinical Support

Hyalomatrix Wound Device

Instructions for Use

Instructions for Use – Hyalomatrix

Clinical Evidence

Use of a Hyaluronic Acid Based Matrix* in the Management of Extremely Recalcitrant Wounds

Nine Patient Evaluation of a Hyaluronic Acid-Based Wound Dressing

Evaluation of the Use of a Hyaluronic Acid Based Wound Dressing with a Silicone Fluid Transfer Dressing

Use of a Novel Hyaluronic Acid Based Device in the Management of Difficult Chronic Wounds

Using aseptic technique, open the outer pouch and pass the inner tray into the sterile field (if applicable). Open the tray and gently remove the product from the protective sheet.

Following wound bed preparation, immediately apply the device, keeping the fibrous HYAFF layer in contact with the wound bed. Hyalomatrix may be cut to size.

Do not overlap Hyalomatrix units. Cover Hyalomatrix with an appropriate, non-adherent secondary dressing.

Published Evidence

Erbatur S, Coban YK, Aydin EN. Comparison of clinical and histopathological results of hyalomatrix usage in adult patients. Int’l Journal of Burns and Trauma. 2012;2(2):118-125.

Caravaggi C, Grigoletto F, Scuderi N. Wound Bed Preparation with a Dermal Substitute (Hyalomatrix PA) Facilitates Re-epithelialization and Healing: Results of a Multicenter, Prospective, Observational Study on Complex Chronic Ulcers (The FAST Study). Wounds. 2011;23(8):228-235.

Motolese A, Vignati F, Brambilla R, Cerati M, Passi A. Interaction between a regenerative matrix and wound bed in nonhealing ulcers: results with 16 cases. Biomed Research International. 2013; 2013:849321.

Faga A, Nicoletti G, Brenta F, Scevola S, Abatangelo G, Brun P. Hyaluronic acid three-dimensional scaffold for surgical revision of retracting scars: a human experimental study. International Wound Journal. 2013 Jun;10(3):329-35.

Vaienti L, Marchesi A, Palitta G, Gazzola R, Parodi PC, Leone F. Limb Trauma: the use of an advanced wound care device in the treatment of full-thickness wounds. Strategies in Trauma and Limb Reconstruction. 2013;8:111-115.

Vindigni V, Cortivo R, Iacobellis L, Abatangelo G, Zavan B. Hyaluronan Benzyl Ester as a Scaffold for Tissue Engineering. International Journal of Molecular Sciences. 2009; 10: 2972-2985.

Osti E. Skin pH Variations from the Acute Phase to Re-Epithelialization in Burn Patients Treated with New Materials (Burnshield, Semipermeable, Adhesive Film, Dermasilk, and Hyalomatrix). Noninvasive preliminary Experimental Clinical Trial. Annals of Burns and Fire Disasters. 2008; 16(2):73-77.

Myers SR, Partha VN, Soranzo C, Price RD, Navsaria HA. Hyalomatrix: a temporary epidermal barrier, hyaluronan delivery, and neodermis induction system for keratinocyte stem cell therapy. Tissue Engineering. 2007 Nov;13(11):2733-41.

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The information on this page is intended for healthcare professionals in the US only. It is provided for informational purposes only and is not intended to replace a discussion with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider and consider the unique characteristics of each patient. If you have product use questions, contact us.

© 2015 Medline Industries, Inc. All rights reserved. Medline is a registered trademark of Medline Industries, Inc. HYAFF® is a registered trademark of Anika Therapeutics S.r.l. Hyalomatrix® is a registered trademark of Fidia Farmaceutici S.p.a.